abstract：BACKGROUND:Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk classification systems, including CAPRA-S, are currently used for disease prognostication. However, high...

journal_title：BMC cancer

authors： Kamdar S,Fleshner NE,Bapat B

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Internal mammary and/or supraclavicular (IM-SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes. METHODS:We enrolled 4237 patients with clinical stage I-IIIC breast cancer treated between January 2007...

journal_title：BMC cancer

authors： Inari H,Teruya N,Kishi M,Horii R,Akiyama F,Takahashi S,Ito Y,Ueno T,Iwase T,Ohno S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Art therapy may improve the physical, mental, and emotional wellbeing of individuals for a variety of purposes. It remains understudied and underutilized in cancer care. We sought to determine the ability of a pilot art therapy program to improve the physical, mental, and emotional well-being of cancer patie...

journal_title：BMC cancer

authors： Elimimian EB,Elson L,Stone E,Butler RS,Doll M,Roshon S,Kondaki C,Padgett A,Nahleh ZA

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutational signature. METHODS:We systematically analyzed the smoking-related DNA methylation sites reported ...

journal_title：BMC cancer

authors： Chen Z,Wen W,Cai Q,Long J,Wang Y,Lin W,Shu XO,Zheng W,Guo X

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The purpose of this study was to investigate the prognostic factors for disease-specific survival at the in...

journal_title：BMC cancer

authors： Shinoda Y,Kobayashi E,Kobayashi H,Mori T,Asano N,Nakayama R,Morioka H,Iwata S,Yonemoto T,Ishii T,Hiruma T,Kawai A,Kawano H

更新日期：2020-09-14 00:00:00

abstract：BACKGROUND:BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting results and insufficient sampling, a meta-analysis was performed to explore the prognostic value of ...

journal_title：BMC cancer

authors： Fang S,Liu Z,Guo Q,Chen C,Ke X,Xu G

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear. METHODS:With the goal of revealing the underlying mechanism, three data sets with accession numbers GSE8401, GSE46517 ...

journal_title：BMC cancer

authors： Su W,Guan Y,Huang B,Wang J,Wei Y,Zhao Y,Jiao Q,Ji J,Yu D,Xu L

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Th...

journal_title：BMC cancer

authors： Hailemariam G,Gebreyesus H,Wubayehu T,Gebregyorgis T,Gebrecherkos K,Teweldemedhin M,Kifle M

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of cancer-related pain in the outpatient setting. METHODS:We conducted a prospective study to compare rein...

journal_title：BMC cancer

authors： Peng Z,Li L,Chen Y,Feng Z,Fang X

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:Endometrial cancer, one of the most common malignant tumors, is a serious threat to women's health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been found to play important roles in many types of cancer. The present study aimed to investigate the e...

journal_title：BMC cancer

authors： Zhang D,Chen X,Xia H,Wang L,Zhao H,Xu B,Zhang A,Zhang W

更新日期：2020-09-03 00:00:00

abstract：BACKGROUND:Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physician factors impact treatment decisions. The purpose of this study was to examine patient and physic...

journal_title：BMC cancer

authors： Schwedhelm TM,Rees JR,Onega T,Zipkin RJ,Schaefer A,Celaya MO,Moen EL

更新日期：2020-09-03 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC cancer

authors： Al-Khayal K,Vaali-Mohammed MA,Elwatidy M,Traiki TB,Al-Obeed O,Azam M,Khan Z,Abdulla M,Ahmad R

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dose-dense chemotherapy may yield favorable outcomes compared with standard-dose chemotherapy, yet the ...

journal_title：BMC cancer

authors： Hsieh CY,Lein MY,Yang SN,Wang YC,Lin YJ,Lin CY,Hua CH,Tsai MH,Lin CC

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Cell-free DNA's (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning guided panel design strategy for improving the detection of tumor variants in cfDNA. Using this app...

journal_title：BMC cancer

authors： Cario CL,Chen E,Leong L,Emami NC,Lopez K,Tenggara I,Simko JP,Friedlander TW,Li PS,Paris PL,Carroll PR,Witte JS

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma (PMBCL). However, their CNA-based profile and clinical impact still remain unc...

journal_title：BMC cancer

authors： Xue X,Huang W,Qiu T,Guo L,Ying J,Lv N

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in monocular patients. METHODS:In this retrospective case series, intravitreal chemotherapy-assisted en...

journal_title：BMC cancer

authors： Yu X,Li X,Xing Y,Lu S,Tanumiharjo S,Ma J

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism. METHODS:The expre...

journal_title：BMC cancer

authors： Tu XP,Li H,Chen LS,Luo XN,Lu ZM,Zhang SY,Chen SH

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor in human. Research has shown that HPV status HNSCC is a unique prognosis factor, which may due to its immune infiltration landscape. But the underlying mechanism is unclear. METHODS:In this study, we used a combination of several b...

journal_title：BMC cancer

authors： Zeng H,Song X,Ji J,Chen L,Liao Q,Ma X

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection of patients who might benefit form adjuvant chemotherapy (ACT). Presence of circulating tumor DNA (ctDNA) is indicative for MRD and has hi...

journal_title：BMC cancer

authors： Schraa SJ,van Rooijen KL,van der Kruijssen DEW,Rubio Alarcón C,Phallen J,Sausen M,Simmons J,Coupé VMH,van Grevenstein WMU,Elias S,Verkooijen HM,Laclé MM,Bosch LJW,van den Broek D,Meijer GA,Velculescu VE,Fijneman RJA,Vin

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a major cause of cancer death. Therefore, identifying potential prognostic risk factors is critical to improve the survival of patients with LUAD. METHODS:Here, relevant datasets were downloaded from TCGA and GEO databases to screen the differentially expressed genes (DEGs). Un...

journal_title：BMC cancer

authors： Jiang H,Xu S,Chen C

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the short- and long-term outcomes after laparoscopic resection for low rectal cancer (LRC) compared with mid/high rectal cancer (M/HRC). METHODS:Patients with rectal cancer undergoing laparoscopic resection with curative intent were retrospectively reviewed between 2009 and 2015...

journal_title：BMC cancer

authors： Yang H,Yao Z,Cui M,Xing J,Zhang C,Zhang N,Liu M,Xu K,Tan F,Su X

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:Ovarian tissue cryopreservation has a wide range of cancerous indications. Avoiding relapse becomes a specific concern that clinicians frequently encounter. The data about the comparative viability of cancer cells after cryopreservation are limited. This study aimed to evaluate the effect of cryopreservation...

journal_title：BMC cancer

authors： Du X,Todorov P,Isachenko E,Rahimi G,Mallmann P,Meng Y,Isachenko V

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor microenvironment. Such models are urgently needed. Mutations of the tumor p...

journal_title：BMC cancer

authors： Ramelow J,Brooks CD,Gao L,Almiman AA,Williams TM,Villalona-Calero MA,Duan W

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:Disparities in multiple myeloma (MM) prognosis based on sociodemographic factors may exist. We investigated whether education level at diagnosis influenced Chinese MM patient outcomes. METHODS:We performed a multicenter retrospective analysis of data from 773 MM patients across 9 centers in China from 2006 ...

journal_title：BMC cancer

authors： Xu L,Wang X,Pan X,Wang X,Wang Q,Wu B,Cai J,Zhao Y,Chen L,Li W,Li J

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:Splenic marginal zone lymphoma (SMZL) is a rare lymphoid B-cell malignant neoplasm with primary involvement of the spleen. It is a chronic disease, of indolent behavior and prolonged survival. However, 25% of cases have higher biological aggressiveness, propensity for histological transformation to high grad...

journal_title：BMC cancer

authors： de Pádua Covas Lage LA,Dos Santos FFC,Levy D,Moreira FR,Couto SCF,Culler HF,de Oliveira Costa R,Rocha V,Pereira J

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. However, the lack of accuracy in identifying HR patients with conventional risk factors (large, deep, ...

journal_title：BMC cancer

authors： Filleron T,Le Guellec S,Chevreau C,Cabarrou B,Lesluyes T,Lodin S,Massoubre A,Mounier M,Poublanc M,Chibon F,Valentin T

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistance. Thus, novel therapeutic approaches are required. Statins and amino-bisphosp...

journal_title：BMC cancer

authors： Göbel A,Zinna VM,Dell'Endice S,Jaschke N,Kuhlmann JD,Wimberger P,Rachner TD

更新日期：2020-07-29 00:00:00

abstract：BACKGROUND:The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic models predict that radon could deliver a carcinogenic dose to breast tissue. Our previous work suggeste...

journal_title：BMC cancer

authors： Peng C,DuPre N,VoPham T,Heng YJ,Baker GM,Rubadue CA,Glass K,Sonawane A,Zeleznik O,Kraft P,Hankinson SE,Eliassen AH,Hart JE,Laden F,Tamimi RM

更新日期：2020-07-28 00:00:00

abstract：BACKGROUND:First-line treatment with FOLFOXIRI plus bevacizumab (BEV) is highly effective and regarded as one of the standards-of-care for patients with metastatic colorectal cancer (mCRC), despite the high incidence of neutropenia and diarrhea as side effects. AXEPT, an Asian phase III study, showed that modified CAPI...

journal_title：BMC cancer

authors： Miyo M,Kato T,Yoshino T,Yamanaka T,Bando H,Satake H,Yamazaki K,Taniguchi H,Oki E,Kotaka M,Oba K,Miyata Y,Muro K,Komatsu Y,Baba H,Tsuji A

更新日期：2020-07-23 00:00:00

abstract：BACKGROUND:There is international interest in risk-stratification of breast screening programmes to allow women at higher risk to benefit from more frequent screening and chemoprevention. Risk-stratification also identifies women at low-risk who could be screened less frequently, as the harms of breast screening may ou...

journal_title：BMC cancer

authors： McWilliams L,Woof VG,Donnelly LS,Howell A,Evans DG,French DP

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Immune checkpoint inhibitors (ICIs) reported remarkable achievements in several solid tumours. However, in metastatic colorectal cancer (mCRC) promising results are limited to patients with deficient mismatch repair/microsatellite instability-high (dMMR/MSI-high) tumours due to their immune-enriched microenv...

journal_title：BMC cancer

authors： Antoniotti C,Borelli B,Rossini D,Pietrantonio F,Morano F,Salvatore L,Lonardi S,Marmorino F,Tamberi S,Corallo S,Tortora G,Bergamo F,Brunella DS,Boccaccino A,Grassi E,Racca P,Tamburini E,Aprile G,Moretto R,Boni L,Fa

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:The aim of this study was to identify gene signatures and prognostic values of m6A methylation regulators in uveal melanoma (UM). METHODS:The RNA sequencing dataset and corresponding clinical information were downloaded from TCGA and GEO database. Based on the expression of m6A RNA methylation regulators, t...

journal_title：BMC cancer

authors： Tang J,Wan Q,Lu J

更新日期：2020-07-18 00:00:00

abstract：BACKGROUND:IMMUNEPOTENT CRP (ICRP) can be cytotoxic to cancer cell lines. However, its widespread use in cancer patients has been limited by the absence of conclusive data on the molecular mechanism of its action. Here, we evaluated the mechanism of cell death induced by ICRP in HeLa and MCF-7 cells. METHODS:Cell deat...

journal_title：BMC cancer

authors： Martínez-Torres AC,Reyes-Ruiz A,Calvillo-Rodriguez KM,Alvarez-Valadez KM,Uscanga-Palomeque AC,Tamez-Guerra RS,Rodríguez-Padilla C

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic si...

journal_title：BMC cancer

authors： Kloker LD,Berchtold S,Smirnow I,Beil J,Krieg A,Sipos B,Lauer UM

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:The failure of treatment for breast cancer usually results from distant metastasis in which the epithelial-mesenchymal transition (EMT) plays a critical role. Hyperinsulinemia, the hallmark of Type 2 diabetes mellitus (T2DM), has been regarded as a key risk factor for the progression of breast cancer. Nuclea...

journal_title：BMC cancer

authors： Xia B,Hou L,Kang H,Chang W,Liu Y,Zhang Y,Ding Y

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:A major cause of disease-related death in nasopharyngeal carcinoma (NPC) is the development of distant metastasis (DM) despite combination chemoradiotherapy treatment. We previously identified and validated a four microRNA (miRNA) signature that is prognostic for DM. In this study, characterization of a key ...

journal_title：BMC cancer

authors： Bissey PA,Teng M,Law JH,Shi W,Bruce JP,Petit V,Tsao SW,Yip KW,Liu FF

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:HOXA family genes were crucial transcription factors involving cell proliferation and apoptosis. While few studies have focused on HOXA10 in AML. We aimed to investigate the prognostic significance of HOXA10. METHODS:We downloaded datasets from GEO and BeatAML database, to compare HOXA expression level betw...

journal_title：BMC cancer

authors： Guo C,Ju QQ,Zhang CX,Gong M,Li ZL,Gao YY

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (PUFAs) were proposed to have potential effects against inflammation and cancer. However, results from epidemiology studies remain inconsistent. We aimed to explore the associations of plasma PUFAs with EC recurrence and all-cause mortality. METHOD:Women diagnosed with en...

journal_title：BMC cancer

authors： Li P,Shan B,Jia K,Hu F,Xiao Y,Zheng J,Gao YT,Wang H,Gao Y

更新日期：2020-06-20 00:00:00

abstract：BACKGROUND:Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This study aims to assess knowledge and attitude towards cervical cancer and its prevention, as well as prac...

journal_title：BMC cancer

authors： Ruddies F,Gizaw M,Teka B,Thies S,Wienke A,Kaufmann AM,Abebe T,Addissie A,Kantelhardt EJ

更新日期：2020-06-17 00:00:00

abstract：BACKGROUND:Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening outcomes within a lung cancer screening program (LCSP) at our urban academic medical center includi...

journal_title：BMC cancer

authors： Lake M,Shusted CS,Juon HS,McIntire RK,Zeigler-Johnson C,Evans NR,Kane GC,Barta JA

更新日期：2020-06-16 00:00:00